Abstract
As a guide to the development of new and more selective inhibitors of phenylethanolamine N-methyltransferase (PNMT) vs the alpha2-adrenoceptor, we have performed a comparative molecular field analysis (CoMFA) on a series of 80 benzylamine analogues. Using the models obtained, we have proposed a series of 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinolines and predicted the activity of other analogues.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology
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Models, Chemical
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Phenylethanolamine N-Methyltransferase / antagonists & inhibitors*
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Phenylethanolamine N-Methyltransferase / chemistry
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Receptors, Adrenergic, alpha-2 / chemistry*
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Receptors, Adrenergic, alpha-2
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Phenylethanolamine N-Methyltransferase